U.S. Secretary of State Marco Rubio said on Thursday the United States will hold direct talks with Iran this weekend to discuss Iran's nuclear program.

The talks between U.S. special envoy Steve Witkoff and a senior Iranian leader are scheduled for Saturday in Oman.

"We hope that'll lead to peace. We've been very clear what Iran is never going to have a nuclear weapon, and I think that's what led to this meeting," Rubio said during a Cabinet meeting chaired by President Donald Trump.

Trump on Monday made a surprise announcement that the United States and Iran were poised to begin direct talks on Tehran's nuclear program on Saturday, warning that Iran would be in "great danger" if the talks were unsuccessful.

The announcement caused some confusion because Iran had said the talks would be indirect with the Omanis acting as mediators.

A U.S. official familiar with the planning said the two delegations would be in the same room for the talks.

Trump on Wednesday repeated his threat to use military force if Iran did not agree to end its nuclear program, saying Israel would play a key role in any military action.

Trump said Iran could not be allowed to have a nuclear weapon and if it declined to stop development efforts, military action could follow.